The behavior of these programs vary, however, you will need to ensure not only are they disconnected and closed, but no longer running in the background in order to play.
To check if these programs are still running and force these programs to quit on:
PC: Press Ctrl+Alt+Delete to access your computer's Task Manager.
Mac: Use the Activity Monitor in the Utilities folder of your Applications.
If this does not resolve the issue, you may need to remove them from your computer completely.
PC: Go to the Control Panel > Programs > Uninstall > and select/remove the program from the list.
Mac: Locate the program in your Applications folder and drag to the trash.